The DeLeon-Pennell Lab focuses on the inflammatory and fibrotic components of cardiac remodeling following a heart attack. Our major research focus is on the role of the adaptive immune system and cellular cross-talk with the innate immune system to regulate cardiac wound healing. These changes include cell-cell and cell-matrix interactions, which both affect and react to processes involved in tissue repair.
Our research focus is on dissecting the interplay of pre-existing variables such as chronic inflammation, stress, or sex/gender on cardiovascular events, which involves:
Developing multidimensional approaches to examine the mechanisms whereby the innate and adaptive immune system influences cardiovascular remodeling
Understanding the dynamics and function of bio-molecules involved in cardiac remodeling
Utilizing the knowledge acquired to develop therapeutic strategies to prevent, slow, or reverse the progression to heart failure
Kudos Corner
Dr. Kristine Y. DeLeon-Pennell, Ph.D.
About the PI:
Dr. DeLeon-Pennell was trained in cardiovascular sciences at Baylor University, University of Texas Health Science Center San Antonio, and the University of Mississippi Medical Center. She has a long-standing career focused on dissecting the role of the inflammatory and fibrotic responses that influence cardiac remodeling following myocardial infarction. She spent her career, starting as an undergraduate, acquiring expertise with leaders in the fields to gain an exceptionally broad skill set in genomics, proteomics, biochemistry, and cellular physiology research. Dr. DeLeon-Pennell has successfully obtained funding from federal and private sources, and established collaborations with scientists both within and outside her institution. Dr. DeLeon-Pennell has affiliation with both The Medical University of South Carolina along with the neighboring Ralph H Johnson VA Medical Center located in beautiful, historic downtown Charleston, SC.
Contact information : deleonky@musc.edu
The content is solely the responsibility of the authors and does not necessarily represent the official views of MUSC or Ralph H Johnson VA Medical Systems.
Disclosures: